Immuno-Ex

For several years now, there has been growing interest in the therapeutic role of aerobic exercise in oncology. The latter enables the mobilization of so-called anti-cancer immune cells, but their ability to reach and destroy tumor cells in individuals undergoing treatment remains to be confirmed. The objectives of the Immuno-Ex study are therefore to evaluate the migratory and functional capacities of T and NK cells mobilized by exercise in patients undergoing treatment for curable cancer, and to compare the effect of two exercise modalities (moderate-intensity continuous exercise (MOD) and high-intensity interval training (HIIT)) on the anti-cancer immune response. Participants will take part in five visits: one assessment visit, two familiarizations with the exercise protocols and two experimental conditions (HIIT and MOD), whose order will be determined randomly. During these, blood samples will be taken before, after and one hour after the end of exercise to isolate peripheral blood mononuclear cells (PBMC). These cells will be used for Transwell type cell migration assays and flow cytometry analysis of their cytotoxic potential. The hypothesis is that exercise will promote cell migration, and these cells will display anti-cancer functional characteristics, suggesting a possible adjuvant and immunotherapeutic use of exercise.

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